DESIGN, SYNTHESIS, AND INVESTIGATION OF NOVEL NITRIC OXIDE (NO)-RELEASING AROMATIC ALDEHYDES AS DRUG CANDIDATES FOR THE TREATMENT OF SICKLE CELL DISEASE

Sickle cell disease (SCD) is caused by a single-point mutation, and the ensuing deoxygenation-induced polymerization of sickle hemoglobin (HbS), and reduction in bioavailability of vascular nitric oxide (NO), contribute to the pathogenesis of the disease.In a proof-of-concept study, we successfully incorporated nitrate ester groups onto two previou

Abstract Background When a randomised trial is subject to deviations from randomised treatment, analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial.Even in trials of a predominantly pragmatic nature, there may be numerous rea

In northwestern Mexico and the southwestern United States, limited water supplies and fragile landscapes jeopardize world-renowned biological diversity.Simple rock detention structures have been used to manage agricultural water for over a thousand years and are now being installed to restore ecohydrological functionality but with little scientific

Elaboration of the technology of novel photolithographic masks fabricated on sapphire substrates for UV and DUV application was described.The main technological steps of mask fabrication as Cr metallization deposition, deva curl arc angel selection of resist for lithography and Cr layer etching were developed and reported.The etching of Cr films wa

This paper proposes a modified harmonic cam, which is used to design a harmonic drive.Conventional harmonic drives using a sinusoidal cam type pertain to an elastic body concept and are thus difficult to design and air jordan retro 11 low ie basketball shoes evaluate.Unlike the conventional sinusoidal cam, the proposed harmonic cam involves a combi